产品信息
商品描述
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo.
分子量
234.3
纯度
>98%
可溶性
DMSO : 43 mg/mL (183.5 mM)
Ethanol : 11 mg/mL (47 mM)
Ethanol : 11 mg/mL (47 mM)
外观
Powder
In vitro(体外研究)
In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.
In vivo(体内研究)
In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.
背景
别名
ISX-9,ISX 9,Neuronal Differentiation Inducer III
分子式
C11H10N2O2S
CAS号
832115-62-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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