产品信息
抗原名称
Adrenergic Receptor
商品描述
Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
分子量
505.05
纯度
>98%
可溶性
Ethanol ：93 mg/mL (184.1 mM)
DMSO ：93 mg/mL (184.1 mM)
Water ：75 mg/mL (148.5 mM)
DMSO ：93 mg/mL (184.1 mM)
Water ：75 mg/mL (148.5 mM)
外观
白色至米黄色粉末
In vivo(体内研究)
Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension.
背景
别名
盐酸伊伐布雷定
分子式
C27H36N2O5.HCl
CAS号
148849-67-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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