产品信息
抗原名称
JARID1A ,JMJD2D ,JMJD2E ,JMJD2B ,JMJD2A
商品描述
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
分子量
308.76
纯度
>98%
可溶性
DMSO ：25 mg/mL warmed (80.96 mM)
外观
Powder
In vitro(体外研究)
JIB-04 induces transcriptional changes in a cancer-selective manner, including the downregulation of proliferative genes and the upregulation of the anti-proliferative/pro-apoptotic genes. JIB-04 blocks growth of lung and prostate cancer lines with IC50 as low as 10 nM, while produces less anti-proliferative activities on HBECs and PrSCs/PrECs.
In vivo(体内研究)
In two separate xenograft mouse models (H358 or A549), JIB-04 diminishes tumor growth, lowers Jumonji histone demethylase activity in tumors, and prolongs cancer survival.
背景
别名
NSC693627,JIB04; JIB 04，NSC-693627，JIB-04,JIB04
分子式
C17H13ClN4
CAS号
199596-05-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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