产品信息
抗原名称
PARP
商品描述
Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.
分子量
317.21
纯度
>98%
可溶性
DMSO : ≥ 3.2 mg/mL (10.09 mM)
外观
白色至类白色粉末
In vivo(体内研究)
The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time.
背景
别名
维利帕尼二盐酸盐；Veliparib dihydrochloride；ABT-888 dihydrochloride
分子式
C13H18Cl2N4O
CAS号
912445-05-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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