产品信息
抗原名称
CFTR
商品描述
Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.
分子量
409.4
纯度
98%
可溶性
DMSO : 40.9 mg/mL (100 mM)
外观
黄色粉末
In vitro(体外研究)
CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl− current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition.
In vivo(体内研究)
CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo.
背景
别名
CFTR Inhibitor-172; CFTRinh-172
分子式
C18H10F3NO3S2
CAS号
307510-92-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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