产品信息
抗原名称
CRTh2 (DP2) receptor
商品描述
AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1
分子量
388.87
纯度
>98%
可溶性
DMSO Solubility: 11 mg/mL (28.28 mM)
外观
Powder
In vitro(体外研究)
AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. AZD1981 blocks DP2-mediated shape change in human eosinophils and basophils in blood, as well as DP2-mediated chemotaxis of human Th2 cells and eosinophils. Moreover, AZD1981 also blocks the binding of PGD2 to mouse, rat, guinea pig, rabbit and dog recombinant DP2.
In vivo(体内研究)
AZD1981 has high oral bioavailability in male sprague dawley rats. In guinea pig hind limb model, AZD1981 (100 nM) completely inhibits DK-PGD2-induced eosinophil mobilization.
背景
别名
AZD-1981; AZD 1981
分子式
C19H17ClN2O3S
CAS号
802904-66-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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