产品信息
抗原名称
EGFR (L858R) ,EGFR (exon 19Del) ,EGFR (WT)
商品描述
AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
分子量
459.90
纯度
>98%
可溶性
DMSO 92 mg/mL (200.04 mM)
Ethanol 44 mg/mL warmed (95.67 mM)
Ethanol 44 mg/mL warmed (95.67 mM)
外观
Powder
In vitro(体外研究)
In H3255 (L858R) cells, AZD3759 inhibits EGFR phosphorylation with IC50 of 7.2 nM. AZD3759 demonstrates inhibitory effects on both the pEGFR pathway and cell proliferation of EGFR mutation-derived cells PC-9 and H3255 with IC50 of 7.7 nM and 7 nM, respectively, showing mo activity on cell proliferation of H838 cells.
In vivo(体内研究)
AZD3759 shows good oral bioavailability in dogs, and penetrates extensively into monkey brain. In a brain metastasis PC-9 (Exon19Del) model, AZD3759 (15 mg/kg) causes significant dose-dependent antitumor efficacy.
背景
别名
AZD-3759,AZD 3759,,AZD3759
分子式
C22H23ClFN5O3
CAS号
1626387-80-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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