产品信息
抗原名称
MMP-1；MMP-2；MMP-9；MMP-7；MMP-3
商品描述
Batimastat (BB-94)是一种有效的，广谱matrix metalloprotease (MMP)（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，IC50分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。
分子量
477.64
纯度
＞98%
可溶性
DMSO : 47.8 mg/mL (100 mM)
外观
white to tan powder
In vitro(体外研究)
Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site.
In vivo(体内研究)
Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures.
背景
别名
巴马司他；BB-94; BB 94; BB94
分子式
C23H31N3O4S2
CAS号
130370-60-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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