HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates.¹ In this way, it impacts development, proliferation, invasion, and tumorigenesis.¹ HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC₅₀ = 36 nM) that poorly blocks other HDAC enzymes.² It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC₅₀ value of 210 nM.²

≥95%