产品信息
抗原名称
Gamma-secretase
商品描述
L-685,458 is a specific and potent inhibitor of A beta PP <b>gamma-secretase</b> activity with <b>K<sub>i</sub></b> of 17 nM.
分子量
672.85
纯度
98%
可溶性
DMSO : 10.1 mg/mL (15 mM)
外观
white solid
In vitro(体外研究)
L-685,458 inhibits Aβ(40) formation in both Neuro2A and CHO cell lines overexpressing human AβPP695, and in SHSY5Y cells overexpressing the construct spβA4CTF with IC50 of 402 nM, 113 nM, and 48 nM, respectively, with the potency for reduction of Aβ(42) being about 2-fold lower. In Tca8113 cells, L-685,458 inhibits cell growth by inducing G0–G1 cell cycle arrest and apoptosis. In a T-cell acute lymphoblastic leukemia cell line, pre-treatment with L-685,458 enhances the anti-proliferative effect of imatinib. L685,458 also significantly reduces HSV-1 replication in tissue culture by inhibiting signal peptide peptidase (SPP).
背景
别名
L-685458
分子式
C39H52N4O6
CAS号
292632-98-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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