产品信息
抗原名称
Syk
商品描述
Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
分子量
732.51
纯度
98%
可溶性
DMSO : 25 mg/mL (34.13 mM; Need ultrasonic)
H2O : 2 mg/mL (2.73 mM; ultrasonic and warming and heat to 60°C)
H2O : 2 mg/mL (2.73 mM; ultrasonic and warming and heat to 60°C)
外观
White Powder
In vivo(体内研究)
Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406.
背景
别名
福他替尼二钠盐六水合物
分子式
C23H24FN6Na2O9P.6H2O
CAS号
914295-16-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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