产品信息
抗原名称
PRMT5
商品描述
EPZ015866(GSK591) is a potent, selective PRMT5 inhibitor.
分子量
380.22
纯度
>98%
可溶性
10 mM in DMSO
外观
Powder
In vitro(体外研究)
In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
背景
别名
EPZ-015866,EPZ 015866，GSK-591,GSK 591,GSK3203591,GSK-3203591,GSK 3203591
分子式
C22H28N4O2
CAS号
1616391-87-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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