产品信息
抗原名称
glucosylceramide synthase
商品描述
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.
分子量
404.54
纯度
>98%
可溶性
10 mM in DMSO
外观
Powder
In vitro(体外研究)
Eliglustat tartrate is designed and developed to inhibit glucosylceramide synthase, the enzyme that catalyzes the formation of glucosylceramide from UDP-glucose and ceramide.The inhibition of glucosylceramide synthase by eliglustat tartrate is highly specific. Eliglustat tartrate displays limited or no activity against a variety of glycosidases. Additionally, no inhibition of sucrase or maltase is observed at drug concentrations up to 10 μM.
In vivo(体内研究)
Preclinical studies in normal mice, rats and dogs with i.v. and oral administration demonstrates significant dose-related decreases in spleen, kidney and liver glucosylceramide content, consistent with prior observations with the palmitoyl homologue.In rodents, Genz-112638 is rapidly metabolized with a half-life of 15–45 minutes.
背景
别名
Genz-99067; Genz99067; Genz 99067; Eliglustat Tartrate; GENZ-112638
分子式
C23H36N2O4
CAS号
491833-29-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/20246.html