产品信息
抗原名称
G9a/GLP
商品描述
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM).
分子量
329.44
纯度
>98%
可溶性
DMSO : 32.9 mg/mL (100 mM)
外观
Powder
In vitro(体外研究)
A-366 has significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2.Treatment of various leukemia cell lines in vitro results in marked differentiation and morphological changes of these tumor cell lines.
In vivo(体内研究)
Treatment of a flank xenograft leukemia model with A-366 results in growth inhibition consistent with the profile of H3K9me2 reduction observed.
背景
别名
A-366；A366；A 366
分子式
C19H27N3O2
CAS号
1527503-11-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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