产品信息
抗原名称
αVβ3 integrin
商品描述
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
分子量
847.72
纯度
>98%
可溶性
DMSO 100 mg/mL (117.96 mM)
Water 100 mg/mL (117.96 mM)
Ethanol 20 mg/mL (23.59 mM)
Water 100 mg/mL (117.96 mM)
Ethanol 20 mg/mL (23.59 mM)
外观
Powder
In vitro(体外研究)
Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).
In vivo(体内研究)
In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.
背景
分子式
C31H43F6N9O12
CAS号
250612-42-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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