产品信息
抗原名称
Akt
商品描述
SC-79 is an activator of Akt; binds to the pleckstrin homology domain of Akt.
分子量
364.78
纯度
≥98%
可溶性
DMSO ：36.5 mg/mL (100 mM)
外观
white to beige Powder
In vitro(体外研究)
SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.
In vivo(体内研究)
In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.
应用
注意事项
SC79结构不适用于HPLC检测，该纯度是根据NMR谱图推测得到的。
背景
分子式
C17H17ClN2O5
CAS号
305834-79-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/20258.html