产品信息
抗原名称
Rac1 ,Rac1b ,Rac2 ,Rac3
商品描述
EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
分子量
581.47
纯度
>98%
可溶性
DMSO 100 mg/mL warmed (171.97 mM)
Water 100 mg/mL (171.97 mM)
Water 100 mg/mL (171.97 mM)
外观
Powder
In vitro(体外研究)
EHT 1864 selectively inhibits Rac-induced lamellipodia formation, and specifically reverses cell transformation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down.
In vivo(体内研究)
EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.
背景
别名
EHT-1864,EHT-1864
分子式
C25H29Cl2F3N2O4S
CAS号
754240-09-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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