产品信息
抗原名称
ERK2 ,ERK1
商品描述
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
分子量
587.67
纯度
>98%
可溶性
DMSO ：10 mg/mL (17 mM) warmed
外观
Powder
In vitro(体外研究)
SCH772984 is a novel, selective and ATP competitive inhibitor of ERK1/2. SCH772984 inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent manner. SCH772984 also inhibits phosphorylation of residues in the activationloop of ERK itself. SCH772984 demonstrates EC50 values
In vivo(体内研究)
SCH772984 induces tumor regressions in xenograft models at tolerated doses. SCH772984 effectively inhibites MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models.
背景
别名
SCH 772984; SCH772984
分子式
C33H33N9O2
CAS号
942183-80-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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