产品信息
抗原名称
ROCK2 ,ROCK1
商品描述
Ripasudil (K-115) is potent <b>ROCK</b> inhibitor with <b>IC50</b> of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
分子量
395.88
纯度
＞98%
可溶性
H2O : ≥ 50 mg/mL (126.30 mM)
DMSO : 25 mg/mL (63.15 mM)
DMSO : 25 mg/mL (63.15 mM)
外观
White to off-white solid
In vitro(体外研究)
In monkey trabecular meshwork (TM) cells, Ripasudil induces retraction and rounding of cell bodies as well as disruption of actin bundles. In Schlemm's canal endothelial (SCE) cells, Ripasudil significantly decreases transendothelial electrical resistance (TEER), increases the transendothelial flux of FITC-dextran, and disrupts cellular localization of ZO-1 expression.
In vivo(体内研究)
In albino rabbits and monkeys, topical instillation of Ripasudil significantly reduces intraocular pressure (IOP) with maximum IOP reduction of 8.55 mmHg and 4.36 mmHg at 0.5 % and 0.4%, respectively. Ripasudil (1 mg/kg daily, p.o.) exerts a neuroprotective effect on retinal ganglion cell (RGC) after optic nerve crush (NC) by suppressing oxidative stress through pathways involving the Nox family in a mouse model.
背景
分子式
C15H23ClFN3O4S
CAS号
887375-67-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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