产品信息
抗原名称
Indoleamine 2,3-Dioxygenase (IDO)
商品描述
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.
分子量
232.21
纯度
>98%
外观
Powder
In vitro(体外研究)
PF-06840003 reverses IDO-1-induced T-cell anergy in vitro.
In vivo(体内研究)
PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours.
背景
别名
PF 06840003,PF-06840003
分子式
C12H9FN2O2
CAS号
198474-05-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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