产品信息
抗原名称
Pim
商品描述
TP-3654是第二代Pim激酶抑制剂，对Pim-1和Pim-3的Ki值分别为5和42 nM。
分子量
418.46
纯度
＞98%
可溶性
DMSO : 50 mg/mL (119.49 mM; Need ultrasonic)
In vitro(体外研究)
TP-3654 demonstrates potent PIM-1 specific cellular activity in the PIM-1/BAD overexpression system with an average EC50 of 67 nM. TP-3654 treatment reduces levels of phospho-BAD in vitro using the bladder cancer cell line UM-UC-3. TP-3654 reduces colony growth of T24 and UM-UC3 cells, confirming the PIM-1–dependent growth for both cell lines.
In vivo(体内研究)
Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity.
背景
分子式
C22H25F3N4O
CAS号
1361951-15-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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