Dabigatran ethyl ester hydrochloride_211914-50-0_Absin
产品信息
抗原名称
Thrombin
商品描述
Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and a thrombin inhibitor.
分子量
536.03
纯度
98%
可溶性
DMSO : ≥ 50 mg/mL (93.28 mM)
H2O : 5 mg/mL (9.33 mM; Need ultrasonic)
H2O : 5 mg/mL (9.33 mM; Need ultrasonic)
In vitro(体外研究)
The Ki of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate.
In vivo(体内研究)
Dabigatran (Ki=4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect.
背景
分子式
C27H30ClN7O3
CAS号
211914-50-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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