ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD₁ and PLD₂ (IC₅₀s = 6 and 20 nM, respectively).¹ It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.¹ ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally.² As PLD₁ and PLD₂ have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.²

≥95%