Deltarasin hydrochloride_1440898-82-7；1613404-76-4_Absin
产品信息
抗原名称
PDEδ
商品描述
Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.
分子量
640.22
纯度
98%
可溶性
DMSO : ≥ 52 mg/mL (81.22 mM)
H2O : 50 mg/mL (78.10 mM; Need ultrasonic)
H2O : 50 mg/mL (78.10 mM; Need ultrasonic)
In vitro(体外研究)
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
In vivo(体内研究)
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
背景
分子式
C40H38ClN5O
CAS号
1440898-82-7；1613404-76-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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