产品信息
抗原名称
PRMT4,PRMT6
商品描述
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells.
分子量
321.29
纯度
>98%
可溶性
DMSO ：56 mg/mL (174.30 mM)
Water ：56 mg/mL (174.30 mM)
Ethanol ：50 mg/mL (155.62 mM)
Water ：56 mg/mL (174.30 mM)
Ethanol ：50 mg/mL (155.62 mM)
外观
Powder
In vitro(体外研究)
MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM. MS049 demonstrated excellent selectivity over a broad range of epigenetic and nonepigenetic targets. In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells.
背景
分子式
C15H24N2O.2HCl
CAS号
2095432-59-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/21344.html