SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs).¹ It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors.^1,2,3 It displays IC₅₀ values of 0.1 to 1.8 µM for modulating ligand binding.^1,2 SCH 202676 may modulate GPCRs via thiol modification.⁴

≥95%