产品信息
抗原名称
CysLT1,MRP1,MRP4,cMOAT
商品描述
MK-571 (L-660711) sodium is a selective, orally active leukotriene D4 receptor antagonist, with Kis of 0.22 and 2.1 nM in guinea pig and human lung membranes.
分子量
537.07
纯度
>98%
可溶性
DMSO : ≥ 33 mg/mL (61.44 mM)
外观
white to beige powder
In vitro(体外研究)
L-660,711 inhibited LTD4 binding in guinea pig lung with a Ki value of 0.22±0.15 nM (n=35) and LTD4 binding in human lung with a Ki value of 2.1±1.8 nM (n=29). L660,711 was essentially inactive versus LTC4 binding with IC50 values of 23±11 μM (n=16) and 32 μM (n=1) in guinea pig and human lung, respectively.
In vivo(体内研究)
MK-571 is well tolerated in healthy young men. After oral administration, MK-571 is rapidly absorbed. The maximum plasma concentration occurring at 1.1-1.5 h at all doses.
背景
分子式
C26H26ClN2O3S2Na
CAS号
115103-85-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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