产品信息
抗原名称
PRMT3
商品描述
SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM).
分子量
298.34
纯度
>98%
可溶性
DMSO : ≥ 100 mg/mL (335.19 mM)
外观
Beige powder
In vitro(体外研究)
In cells, SGC707 binds to PRMT3 and reduces PRMT3-dependent H4R3me2a. SGC707 also stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
In vivo(体内研究)
In CD-1 male mice, SGC707 (30 mg/kg, i.p.) gives good plasma exposure over 6 h with the peak plasma level of 38000 nM, which suggests that SGC707 is suitable for animal studies.
背景
分子式
C16H18N4O2
CAS号
1687736-54-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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