产品信息
抗原名称
late INa
商品描述
GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa).
分子量
347.22
纯度
>98%
可溶性
10 mM in DMSO
外观
Powder
In vitro(体外研究)
GS967 (3 μM) has no significant effect on L- or T-type calcium channel currents or Na+-Ca2+ exchanger current (INCX), and 1 μM GS967 has minimal or no effect on the ATP-inhibited K+ current or on human cardiac ion channels expressed in human embryonic kidney 293 or Chinese hamster ovary cells. GS967 is a novel sodium channel modulatorspecifically developed to inhibit persistent sodium current, with a 42-fold preference for persistent as opposed to peakcurrent inhibition.
In vivo(体内研究)
GS967 protects against seizures and prematurelethality in vivo. Chronic GS967 does not cause overt behavioraltoxicity or sedation in wild-type mice at theeffective anticonvulsant dose. GS967 suppresses arrhythmogenicity evoked by ischemia, hypokalemia, and catecholamines in canine and porcine models.
背景
别名
GS-967,GS 967,GS-458967; GS 458967; GS458967
分子式
C14H7F6N3O
CAS号
1262618-39-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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