产品信息
抗原名称
GSK-3β；GSK-3α
商品描述
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
分子量
512.53
纯度
＞98%
可溶性
DMSO : 93 mg/mL (181.5 mM)
Ethanol : 2 mg/mL warmed (3.9 mM)
Ethanol : 2 mg/mL warmed (3.9 mM)
外观
yellow to orange powder
In vitro(体外研究)
LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.
In vivo(体内研究)
LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts.
背景
别名
LY 2090314；LY-2090314
分子式
C28H25FN6O3
CAS号
603288-22-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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