产品信息
抗原名称
20S proteasome β5,20S proteasome LMP7
商品描述
Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.
分子量
532.61
纯度
>98%
可溶性
DMSO : 93 mg/mL (174.6 mM)
外观
白色至类白色粉末
In vitro(体外研究)
The anti-MM activity of Oprozomib is associated with activation of caspase-8, caspase-9, caspase-3, and PARP, as well as inhibition of migration of MM cells and angiogenesis.
In vivo(体内研究)
Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80% proteasome inhibition in most tissues and elicited an antitumor response in multiple human tumor xenograft and mouse syngeneic models .
背景
别名
Oprozomib;ONX-0912; ONX0912; ONX 0912; PR-047; PR047; PR 047
分子式
C25H32N4O7S
CAS号
935888-69-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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