产品信息
抗原名称
HDAC4
商品描述
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.
分子量
406.36
纯度
>98%
可溶性
DMSO ：81 mg/mL (199.33 mM)
Ethanol ：11 mg/mL warmed (27.06 mM)
Ethanol ：11 mg/mL warmed (27.06 mM)
外观
White to light yellow Powder
In vitro(体外研究)
Tasquinimod inhibits tumor angiogenesis by allosteric inhibition of HDAC4/N-CoR/HDAC3 dependent deacetylation of HIF-1α. Tasquinimod also targets infiltrating myeloid cells, and modulates local tumour immunity by blocking the interaction between S100A9 and its ligands receptor of advanced glycation end products and Toll-like receptor 4.
In vivo(体内研究)
Tasquinimod (30 mg/kg/d p.o.) shows anti-angiogenic activity and thus causes tumor growth inhibition in mice bearing human and rodent prostate cancer models.
背景
别名
他喹莫德
分子式
C20H17F3N2O4
CAS号
254964-60-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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