产品信息
抗原名称
Pim1；Pim3；Pim2
商品描述
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
分子量
379.48
纯度
＞98%
可溶性
DMSO : 28.5 mg/mL (75.10 mM; Need ultrasonic and warming)
外观
Light yellow to yellow Powder
In vitro(体外研究)
AZD1208 is an orally available, potent and highly selective Pim inhibitor that effectively inhibits all three isoforms. AZD1208 inhibits the growth of several AML cell lines and sensitivity correlates with the level of Pim-1 expression, STAT5 activation and presence of protein tyrosine kinase mutation. AZD1208 causes cell cycle arrest and apoptosis in MOLM-16 cells in culture. This is accompanied by a dose-dependent reduction in phosphorylation of BAD, 4EBP1 and p70S6K. In addition, AZD1208 leads to potent inhibition of colony growth of primary AML cells from bone marrow aspirates and downregulates phosphorylation of Pim targets.
In vivo(体内研究)
AZD1208 suppresses the growth of MOLM-16 and KG-1a xenograft tumors in vivo in a dose proportional manner.
背景
别名
AZD-1208；AZD1208；AZD 1208.
分子式
C21H21N3O2S
CAS号
1204144-28-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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