产品信息
抗原名称
PKA,ROCK2,ROCK1,p70S6K,Akt1
商品描述
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
分子量
313.78
纯度
>98%
可溶性
DMSO Solubility: 62 mg/mL (197.59 mM)
In vitro(体外研究)
AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling.
In vivo(体内研究)
AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts.
背景
别名
AT 13148；AT-13148
分子式
C17H16ClN3O
CAS号
1056901-62-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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