产品信息
抗原名称
Histone Acetyltransferase
商品描述
MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF.
分子量
340.46
纯度
>98%
可溶性
DMSO : ≥ 100 mg/mL (293.72 mM)
In vitro(体外研究)
MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05).
背景
别名
MG 149；MG-149；Tip60 HAT inhibitor
分子式
C22H28O3
CAS号
1243583-85-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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