产品信息
抗原名称
FAP；PREP
商品描述
SP-13786 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM; also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.
分子量
344.32
纯度
98%
可溶性
DMSO ：69 mg/mL (200.39 mM)
Ethanol：5 mg/mL (14.52 mM)
Ethanol：5 mg/mL (14.52 mM)
In vitro(体外研究)
SP-13786 is also found to have better FAP/PREP selectivity and a very proficient ligand efficiency of 0.34.
In vivo(体内研究)
SP-13786 is the most extensive and prolonged inhibitior of FAP in the PK studies. No tight binding behavior is observed, and the inhibitor proves to bind reversibly to FAP. Pharmacokinetic evaluation in mice of SP-13786 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.
背景
别名
UAMC-1110； FAP-IN-1
分子式
C17H14F2N4O2
CAS号
1448440-52-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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