产品信息
抗原名称
angiogenesis
商品描述
Xylitol is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
分子量
152.15
纯度
>98%
可溶性
DMSO : 28 mg/mL (184 mM)
Water : 28 mg/mL (184 mM)
Water : 28 mg/mL (184 mM)
外观
白色结晶粉末
In vitro(体外研究)
Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs.
In vivo(体内研究)
Xylitol triggers the release of insulin in dogs and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug.
背景
别名
木糖醇；Xylite
分子式
C5H12O5
CAS号
87-99-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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