产品信息
抗原名称
EBP1,IκB kinase
商品描述
WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
分子量
568.59
纯度
>98%
可溶性
DMSO 100 mg/mL (175.87 mM)
Ethanol 100 mg/mL (175.87 mM)
Ethanol 100 mg/mL (175.87 mM)
外观
Powder
In vitro(体外研究)
WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6.
In vivo(体内研究)
In RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number.
背景
别名
WS-6，WS 6
分子式
C29H31F3N6O3
CAS号
1421227-53-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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