Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.¹ Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI₅₀ = 1-5 µM).^2,3,4 It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.^3,4 Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.⁵ Jacaric acid inhibits cyclooxygenase-1 in vitro (K_i = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.^6,7

≥95%