NVP DPP 728 dihydrochloride_247016-69-9；207556-62-5_Absin
产品信息
商品描述
NVP DPP 728 is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.
分子量
371.27
纯度
>98%
可溶性
Water ： ≥ 40 mg/mL
外观
Powder
In vitro(体外研究)
NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
In vivo(体内研究)
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
背景
别名
NVPDDP 728；NVP DPP728
分子式
C15H18N6O•2HCl
CAS号
247016-69-9；207556-62-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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