产品信息
抗原名称
p38 MAPK
商品描述
Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.
分子量
383.46
纯度
>98%
可溶性
DMSO ：76 mg/mL (198.19 mM)
Ethanol：41 mg/mL warmed (106.92 mM)
Ethanol：41 mg/mL warmed (106.92 mM)
外观
White to off-white powder
In vivo(体内研究)
In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β).
背景
别名
洛批莫德
分子式
C22H26FN3O2
CAS号
585543-15-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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