产品信息
抗原名称
CRFR
商品描述
R121919 is a potent small-molecule CRF1 receptor antagonist.
分子量
380.53
纯度
>98%
可溶性
DMSO: 6.2 mg/mL (Need ultrasonic)
In vitro(体外研究)
R121919 is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor (Ki=2–5 nM) and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.
In vivo(体内研究)
R121919 reduces measures of both anxiety and depression in the depressed patients. R121919 dose dependently decreases adrenocorticopin hormone and corticosterone responses to restraint stress in rats. Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10 mg/kg R121919 are 9 and 25%, respectively. R121919 reduces levels of anxiety in mice with a steep dose-response curve. Molecules such as GR, MR, BAG-1 and AP-1 have been identified as some of the drug's intracellular targets.
背景
别名
NBI30775; R 121919; R-121919
分子式
C22H32N6
CAS号
195055-03-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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