产品信息
抗原名称
STAT
商品描述
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5.
分子量
610.59
纯度
>98%
可溶性
DMSO 100 mg/mL (163.77 mM)
Ethanol 50 mg/mL warmed (81.88 mM)
Water slightly soluble or insoluble
Ethanol 50 mg/mL warmed (81.88 mM)
Water slightly soluble or insoluble
In vivo(体内研究)
SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors.
背景
别名
SH454
分子式
C29H27F5N2O5S
CAS号
1456632-40-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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