产品信息
抗原名称
G-quadruplex
商品描述
360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.
分子量
703.31
纯度
>98%
可溶性
DMSO : 2 mg/mL (2.84 mM; Need ultrasonic)
In vitro(体外研究)
360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.
背景
别名
360 A iodide
分子式
C27H23I2N5O2
CAS号
737763-37-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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