产品信息
抗原名称
Antibody-drug Conjugate
商品描述
VcMMAE是抗体偶联药物（ADC）中的抗有丝分裂剂，由一甲基阿里他汀E（MMAE）与二肽缬氨酸-瓜氨酸（Vc）交联而成。
分子量
1316.63
纯度
＞98%
可溶性
DMSO: ≥ 54 mg/mL
In vitro(体外研究)
Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells.
In vivo(体内研究)
Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models.
背景
分子式
C68H105N11O15
CAS号
646502-53-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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