产品信息
抗原名称
TRPC4
商品描述
ML 204 isa blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively).
分子量
226.32
纯度
>98%
可溶性
DMSO : ≥ 37 mg/mL (163.49 mM)
外观
Powder
In vitro(体外研究)
ML204 inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 block of TRPC4β channels is not dependent upon GPCR activation. Selectivity studies show no appreciable block by 10-20 μM ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. ML204 blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors.
背景
别名
4-甲基-2-(1-哌啶基)喹啉；ML-204；ML204
分子式
C15H18N2
CAS号
5465-86-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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