产品信息
抗原名称
HIF_HIF Prolyl-Hydroxylase
商品描述
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor).
分子量
175.14
纯度
>98%
可溶性
DMSO : 101.5 mg/mL (579.54 mM)
Ethanol : 35 mg/mL (199.84 mM)
Ethanol : 35 mg/mL (199.84 mM)
外观
白色或类白色粉末
In vitro(体外研究)
DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.
In vivo(体内研究)
DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
背景
别名
二甲基乙二酰氨基乙酸；DMOG；Dimethyloxallyl glycine,
分子式
C6H9NO5
CAS号
89464-63-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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