产品信息
抗原名称
B-Raf (V600E) ,B-Raf ,C-Raf
商品描述
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.
分子量
519.56
纯度
>98%
可溶性
DMSO ：28 mg/mL (53.9 mM)
外观
Powder
In vitro(体外研究)
Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E.
In vivo(体内研究)
Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice.
背景
别名
GSK2118436A (Dabrafenib); GSK-2118436B (Dabrafenib Mesylate);GSK-2118436A; GSK-2118436; GSK2118436A; GSK2118436A; GSK 2118436; GSK 2118436
分子式
C23H20F3N5O2S2
CAS号
1195765-45-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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