(±)-CP 55,940 was one of the first bicyclic mimetics of Δ⁹-THC found to have superior analgesic properties.^1,2 The racemic mixture of CP 55,940 is 20- to 100-fold more effective than Δ⁹-THC in altering the reactions to thermal, mechanical and chemical pain in mice (e.g., 50% maximum possible effect (MPE50) observed in the tail clamp assay at 0.46 and 29.1 mg/kg for (±)-CP 55,940 and Δ⁹-THC, respectively).¹ CP 55,940 has also been used to identify and characterize the central cannabinoid (CB₁) receptor in rat brain membranes.² The capacity to displace CP 55,940 from CB₁ receptor in rat brain preparations has frequently been used in the characterization of novel cannabimimetics.

≥98%