GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).^1,2,3 It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.^4,2 GPR35 is overexpressed in gastric cancer cells.⁵ CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a K_i value of 12.8 nM.⁶ It less potently blocks activation of GPR35 by zaprinast  (IC₅₀ = 160 nM).⁷ It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC₅₀ = 9.08 µM).⁷

≥95%